[SMM Precious Metals Express]
A research team at Utkal University in India has published a review on organoiridium(III) anticancer complexes, focusing on how Schiff base and oxime ligands affect the biological activity, cytotoxicity and mechanisms of action of Ir(III) complexes. Platinum-based drugs such as cisplatin, carboplatin and oxaliplatin have demonstrated that platinum-group metals (PGMs) can be developed into large-scale clinical therapeutics. However, nephrotoxicity, drug resistance and non-selective damage to healthy cells are driving metal-drug research to extend toward other PGMs including ruthenium (Ru), iridium (Ir) and osmium (Os).